Claire Shepherdprofile image

Claire Shepherd

Current Appointments

Director Sydney Brain Bank
Conjoint Lecturer in Pathology, UNSW

Dr Claire Shepherd is the Director of the Sydney Brain Bank at Neuroscience Research Australia. She trained in neuroscience and completed her PhD in Alzheimers disease at the University of Sheffield, UK. After completing her PhD she relocated to Sydney to pursue her interest in the neuropathology of dementia. Soon after her move, Claire was awarded the prestigious Rolf Edgar Lake Fellowship from the University of Sydney and subsequently directed a National Health and Medical Research Council (NHMRC) project grant as CIA. In 2000 Claire was awarded the inaugural Franz Nissl Young Investigator Prize in Neuroscience in recognition of achievements in her early post-doctoral years. She now runs the Sydney Brain Bank, which is a research facility that collects, characterises and stores brain tissue for research into neurodegenerative disease. Claire is also the Director of the Shepherd Dementia Research Laboratory at NeuRA and lead investigator on the NeuRA Volunteers Brain Donor Program a longitudinal research program aimed at investigating the clinical consequences of the cellular changes that occur during ageing. In October 2019, Claire received funding from the Brain Foundation for a new research program that will investigate the presence of chronic traumatic encephalopathy (CTE) in the brain tissue of a large population of well-characterised individuals held by the Sydney Brain Bank and determine any association with repetitive traumatic brain injury exposure. On 27 November, the National Rugby League (NRL) announced support of a Newcastle University-based research program for former players. The participants in this program will be invited to donate their brains to the Sydney Brain Bank after death to facilitate medical research.  This is part of Claire's newest research into how sports-related brain changes impact on a players quality of life.


2023, 01 Mar

Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis

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2022 Sep

Post-mortem brain histological examination in the substantia nigra and subthalamic nucleus in Parkinson's disease following deep brain stimulation.

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2022, 04 Jul

Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank

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2021, 13 Jul

Aging-Related Tau Astrogliopathy in Aging and Neurodegeneration

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2021 Apr

Coexisting Lewy body disease and clinical parkinsonism in amyotrophic lateral sclerosis.

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2021 Mar

Globular glial tauopathy with a mutation in MAPT and unusual TDP-43 proteinopathy in a patient with behavioural-variant frontotemporal dementia.

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2020 Oct

A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes.

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2020, 02 Jul

Alzheimer's amyloid‐β and tau protein accumulation is associated with decreased expression of the LDL receptor‐associated protein in human brain tissue

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2020, 03 Jun

Are mutations in MAPT associated with GGT type III?

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2020 Mar

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.

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