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There are a growing number of studies using mediation analysis to understand the mechanisms of health interventions and exposures. Recent work has shown that the reporting of these studies is heterogenous and incomplete. This problem stifles clinical application, reproducibility, and evidence synthesis. The development and implementation of A Guideline for Reporting Mediation Analyses (AGReMA) will improve the standardization, transparency, and completeness in the reporting of studies that use mediation analysis to understand the mechanisms of health interventions and exposures.
AGReMA Publications
- Cashin, A. G., McAuley, J. H., & Lee, H. (2022). Advancing the reporting of mechanisms in implementation science: A guideline for reporting mediation analyses (AGReMA). Implement Res Pract, 3, 26334895221105568. doi:10.1177/26334895221105568
- Cashin, A. G., Lee, H., Traeger, A. C., Moseley, G. L., Hübscher, M., Kamper, S. J., Skinner, I. W., & McAuley, J. H. (2022). Producing Clinically Meaningful Reductions in Disability: A Causal Mediation Analysis of a Patient Education Intervention. J Pain, 23(2), 236 – 247. doi:10.1016/j.jpain.2021.07.007
- Rizzo, R. R. N., Cashin, A. G., Bagg, M. K., Gustin, S. M., Lee, H., & McAuley, J. H. (2022). A Systematic Review of the Reporting Quality of Observational Studies That Use Mediation Analyses. Prev Sci, 23(6), 1041 – 1052. doi:10.1007/s11121-022 – 01349‑5
- VanderWeele, T. J., Cashin, A. G., McAuley, J. H., & Lee, H. (2022). A New Tool for Reporting Mediation Analyses. Epidemiology, 33(4), e16-e18. doi:10.1097/EDE.0000000000001475
- Cashin, A. G., McAuley, J. H., & Lee, H. (2022). A reporting guideline for randomized trials and observational studies using mediation analysis: AGReMA. Nat Med, 28(3), 432 – 434. doi:10.1038/s41591-021 – 01674‑2
- Lee, H., Cashin, A. G., Lamb, S. E., Hopewell, S., Vansteelandt, S., VanderWeele, T. J., MacKinnon, D. P., Mansell, G., Collins, G. S., Golub, R. M., McAuley, J. H., group, A. G., Localio, A. R., van Amelsvoort, L., Guallar, E., Rijnhart, J., Goldsmith, K., Fairchild, A. J., Lewis, C. C., Kamper, S. J., Williams, C. M., & Henschke, N. (2021). A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement. JAMA, 326(11), 1045 – 1056. doi:10.1001/jama.2021.14075
- Cashin, A. G., McAuley, J. H., Lamb, S., Hopewell, S., Kamper, S. J., Williams, C. M., Henschke, N., & Lee, H. (2020). Items for consideration in a reporting guideline for mediation analyses: a Delphi study. BMJ Evid Based Med. doi:10.1136/bmjebm-2020 – 111406
- Cashin AG, McAuley JH, Lamb SE, Hopewell S, Kamper SJ, Williams CM, Henschke N, Lee H. (2020). Development of A Guideline for Reporting Mediation Analyses (AGReMA). BMC Med Res Methodol 20(1):19. doi: 10.1186/s12874-020‑0915‑5. PMID: 32013883
- Cashin, A. G., Lee, H., Lamb, S. E., Hopewell, S., Mansell, G., Williams, C. M., Kamper, S. J., Henschke, N., & McAuley, J. H. (2019). An overview of systematic reviews found suboptimal reporting and methodological limitations of mediation studies investigating causal mechanisms. J Clin Epidemiol, 111, 60 – 68.e61. doi:10.1016/j.jclinepi.2019.03.005
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