Research Project
Sophie Debs
Current Appointments
PhD CanditateKey Research Areas
Sophie completed a Bachelor of Science in Cell Pathology (Honours Class I) and Psychology at The University of Sydney in 2017. She completed her honours project at The Vascular Immunology Unit, where she examined how inflammation and microvesicles derived from brain endothelial cells contribute to the pathogenesis of cerebral malaria. Sophie has since worked as a Research Assistant at The Garvan Institute of Medical Research and as a Scientist at The Australian Red Cross Blood Service within the NSW Transplantation and Immunogenetics Laboratory. In 2019, Sophie joined NeuRA as a PhD candidate in the Preclinical Schizophrenia Research Laboratory led by Dr. Tertia Purves-Tyson, and in 2022, she was awarded the NeuRA PhD Pearl Scholar Award. Sophie’s research investigates the relationships between neuroinflammation, stress and dopamine dysregulation in schizophrenia, and how estrogen-based therapies may impact these. A key aspect of Sophie’s PhD work involves investigating whether alterations in microglial cell function underlie some of the beneficial effects of estrogen-based therapies observed in people with schizophrenia. It is Sophie’s hope that this fundamental knowledge represents a step forward in discovering new treatment options for people with schizophrenia, thereby improving the quality of life for those affected by severe mental illness.
Publications
2024 Sep
Molecular evidence of altered stress responsivity related to neuroinflammation in the schizophrenia midbrain
View full journal-article on https://doi.org/10.1016/j.jpsychires.2024.07.004
2024 May
Maternal immune activation and estrogen receptor modulation induce sex-specific dopamine-related behavioural and molecular alterations in adult rat offspring
View full journal-article on http://dx.doi.org/10.1016/j.bbi.2024.02.034
2023, 01 Mar
Pain-resolving immune mechanisms in neuropathic pain
View full journal-article on http://dx.doi.org/10.1038/s41582-023-00777-3
2022 May
Disrupting circadian rhythms promotes cancer-induced inflammation in mice
View full journal-article on https://doi.org/10.1016/j.bbih.2022.100428
2019 Feb
Interplay of extracellular vesicles and other players in cerebral malaria pathogenesis
View full journal-article on http://dx.doi.org/10.1016/j.bbagen.2018.10.012
2018 Jun
Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach
View full journal-article on http://dx.doi.org/10.1016/j.tem.2018.03.014