Role of the glycogen synthase kinase-3 (GSK3B) and microtubule associated protein Tau (MAPT) genes in neurodegeneration

Both GSK3B and MAPT genes control crucial processes in the cell. We have shown that genetic polymorphisms in these two genes interact to increase risk for late-onset, idiopathic neurodegeneration. We aim to discover whether the two genes will have an effect in other diseases and to determine the biological mechanisms in the genes act to increase disease risk. An interesting adjunct to this research is the examination of how lifestyle’ factors, such as smoking and a diet of green leafy vegetables, can impact on how the two genes are expressed in our bodies. We are currently examining a large cohort of elderly Australians who have detailed records of their daily habits, to determine whether some lifestyle factors can significantly impact on the activity of GSK3B and MAPT.

Donate to us

Every dollar of community support enables our scientists to continue making life-changing discoveries that contribute to a brighter and healthier future.


Fundraise for us

Run, swim or bake your way to making a positive difference in the lives of people touched by brain and nervous system disorders.

Get involved