The Laboratory of ImmunoPsychiatry is determining the role of resident immune cells (microglia) in the pathophysiology of inflammation-induced depression. Using animal models they are determining whether suppressing activation of these cells can prevent or treat depression-like behaviour. They are also determining whether enhancing transport of excess glutamate produced by these cells from the brain and across the blood-brain-barrier for metabolism in the body is an effective treatment for inflammation-induced depression.