Tertia Purves-Tysonprofile image

Tertia Purves-Tyson

Current Appointments

Senior Research Scientist
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Current research focuses on the molecular/mechanistic understanding of how sex steroid signaling and neuroinflammation interact and contribute to striatal and cortical modulation of dopamine and how dopamine-related behaviours (psychotic-like symptoms, memory and cognition) are altered by sex steroids in male and female rats of different ages. The goal is to transfer this knowledge to human studies to develop or enhance sex steroid based and immune-related treatments for the cognitive and psychotic symptoms of schizophrenia in an age and gender-specific manner.

Dr Purves-Tyson completed a PhD at Manchester University, UK, implicating the mitogen-activated protein kinases in the aetiology of diabetic sensory neuropathy. She relocated to Australia in 2002 to investigate sex steroid signalling mechanisms in pelvic autonomic and sensory neurons. She was awarded an NHMRC Biomedical Training Fellowship and a Ramaciotti Foundation Establishment gift in 2004 to examine the effects of oestrogen on signalling mechanisms on the pelvic autonomic nervous system in diabetes.



GRIN2B gene expression is increased in the anterior cingulate cortex in major depression

View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85148770723&partnerID=MN8TOARS

2022 Nov

The Role of the Microbiome in the Metabolic Health of People with Schizophrenia and Related Psychoses: Cross-Sectional and Pre-Post Lifestyle Intervention Analyses

View full journal-article on https://www.mdpi.com/2076-0817/11/11/1279


Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology

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Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia

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Inflammation-related transcripts define “high” and “low” subgroups of individuals with schizophrenia and bipolar disorder in the midbrain

View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85134309867&partnerID=MN8TOARS


Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants

View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85123621360&partnerID=MN8TOARS


N-Methyl-D-Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia

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2021 Dec

Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia

View full journal-article on https://doi.org/10.1186/s13041-021-00805-7

2021, 05 Mar

Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation

View full journal-article on https://doi.org/10.1038/s41380-019-0434-0


Cortisol-dehydroepiandrosterone ratios are inversely associated with hippocampal and prefrontal brain volume in schizophrenia

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