Research Project
Dr
Bill Brooks
Current Appointments
Senior Research Fellow (Honorary)
Conjoint Senior Lecturer, Prince of Wales Clinical School, UNSW
Honorary Visiting Medical Officer, Cognitive Disorders Clinic, Prince of Wales Hospital
Key Research Areas
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Dr Bill Brooks graduated in Medicine from the University of Sydney in 1978. Since 1988 he has been studying families with the inherited forms of Alzheimer’s disease and similar conditions including familial frontotemporal dementia, initially at Concord Hospital and the University of Sydney. He moved to the NeuRA campus in 2002. His work involves collaboration with the Schofield and Kwok groups for genetic studies and the Halliday group for neuropathological research, as well as the Frontier group for frontotemporal dementia research. Bill is currently working on the DIAN study (Dominantly Inherited Alzheimer Network), an international study of familial Alzheimer’s disease funded by the US National Institute on Ageing.
Publications
2022 Feb
Confirming Pathogenicity of the F386L PSEN1 Variant in a South Asian Family With Early-Onset Alzheimer Disease
View full journal-article on https://doi.org/10.1212/NXG.0000000000000647
2020
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85081697081&partnerID=MN8TOARS
2020
Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85082547156&partnerID=MN8TOARS
2020
CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85082342425&partnerID=MN8TOARS
2019
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85074211513&partnerID=MN8TOARS
2019
Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85061783606&partnerID=MN8TOARS
2019
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85058010718&partnerID=MN8TOARS
2019
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85060347238&partnerID=MN8TOARS
2018
A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85054408708&partnerID=MN8TOARS
2018
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
View full journal-article on http://www.scopus.com/inward/record.url?eid=2-s2.0-85041689945&partnerID=MN8TOARS
Bill's research projects and related news
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